Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke
نویسندگان
چکیده
منابع مشابه
dysphagia in acute ischemic stroke
Introduction: Swallowing dysfunction complicates acute strokes in 25-32% of cases and directly affects patientschr('39') prognosis and recovery. Dysphagia complicates the course of acute strokes through its potential of the development of chest infection, nutritional problems, and dehydration. Dysphagia is also an independent predictor of respiratory morbidity and mortality in acute stroke. In...
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Introduction: stroke is the most important brain disease. Stroke leads to a reduction in bone density, altered calcium homeostasis, and an increase in hip fractures. Some recent studies show effects of vitamin D on stroke and vice versa. The purpose of this study was to determine of serum vitamin D levels in patients with acute stroke. Methods: In this cross-sectional study, we compared t...
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Ischemic stroke has been classified as a merely thrombotic disease, so the main goal of its treatment is the recanalization of the occluded vasculature. However, despite fast restoration of blood circulation, progressive stroke still develops in many patients, which has led to the concept of reperfusion injury. The underlying mechanism is only partly known. Though, it is accepted now, tha...
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OBJECTIVE Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI white matter changes. We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV). METHODS In this multicenter, mitochondrial genome-wide association study (GWAS), 2284 isc...
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Sex differences in neuronal susceptibility to ischemic injury and neurodegenerative disease have long been observed, but the signaling mechanisms responsible for those differences remain unclear. Primary disassociated embryonic neuronal culture provides a simplified experimental model with which to investigate the neuronal cell signaling involved in cell death as a result of ischemia or disease...
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ژورنال
عنوان ژورنال: Disease Models & Mechanisms
سال: 2019
ISSN: 1754-8411,1754-8403
DOI: 10.1242/dmm.033860